Systemic Sclerosis (Scleroderma)
ثبت نشده
چکیده
Systemic sclerosis (SSc) is a multisystem autoimmune disease in which there is increased fibroblast activity resulting in abnormal growth of connective tissue. This causes vascular damage and fibrosis. Fibrosis occurs in skin, the gastrointestinal (GI) tract, heart, lungs and other internal organs. Vascular manifestations include secondary Raynaud's phenomenon, ischaemia of extremities, pulmonary arterial hypertension and renal disease.
منابع مشابه
Systemic Sclerosis (Scleroderma)
labmedicine.com November 2005 Volume 36 Number 11 LABMEDICINE 723 Systemic sclerosis is a chronic disease of unknown etiology characterized by abnormal accumulation of fibrous tissue in the skin and multiple organs.1 Scleroderma derives its name from the Greek words “sclerosis” (hardness) and “derma” (skin), thus aptly named “hard skin,” a feature that is common to all the different types of sc...
متن کاملCutaneous Myxoid Cyst on the Sclerotic Finger in a Patient with Diffuse Systemic Sclerosis
Skin tumors occurring on the scleroderma fingers are rarely seen. Swollen fingers are hallmarks of systemic sclerosis, and mucin deposition in the lesional skin is a constant feature in systemic sclerosis. Here we describe a case of cutaneous myxoid cyst on the flexor aspect of the sclerotic fingers in a patient with severe diffuse cutaneous systemic sclerosis. Cutaneous myxoid cyst is a relati...
متن کاملDystrophic Calcinosis in a Patient with Scleroderma: Imaging Findings and Literature Review
Subcutaneous calcinosis consists of abnormal calcium deposition in soft tissues and is one of the complications of scleroderma, especially in limited systemic sclerosis. It is one of the criteria of CREST syndrome (calcinosis cutis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia). A 44-year-old woman with systemic scleroderma for 20 years was presented with pain ...
متن کاملScleroderma Renal Crisis in a Normotensive Patient
INTRODUCTION S ystemic sclerosis (scleroderma) is an autoimmune disorder of unclear etiology that leads to fibrosis and vascular injury of the skin and multiple organs, including the lungs, heart, gastrointestinal tract, kidneys, and the musculoskeletal system. It is classified as either diffuse or limited cutaneous based on the extent of skin thickening. In the diffuse form of systemic scleros...
متن کاملScleroderma with Nodular Scleroderma
BACKGROUND Nodular scleroderma is a rare variant of scleroderma which can occur in connection with systemic sclerosis or morphea. A biopsy from the lesion can demonstrate the scleroderma pattern, i.e., keloid pattern or mixed type. Treatment is challenging, and several treatments modalities have been reported with unsatisfactory results. MAIN OBSERVATIONS We present a case of systemic scleros...
متن کاملAntiubiquitin antibody in localised and systemic scleroderma.
OBJECTIVE To determine the presence of antiubiquitin antibody (AUbA) in localised scleroderma and systemic sclerosis, as it is frequently found in the sera of patients with systemic lupus erythematosus (SLE) and has also been shown to have a close relationship with antihistone antibodies that have an important role in scleroderma. METHODS Serum samples from patients with localised scleroderma...
متن کامل